石宝宝

石宝宝

民族：汉族

职称：副教授（硕士研究生导师）

学科专业：药物化学

研究方向：天然药物化学/真菌化学

电子邮箱：2021068@mail.scuec.edu.cn

一、教育和工作经历

2025.12-至今：中南民族大学，药学院，副教授

2021.07-2025.12：中南民族大学，药学院，讲师

2018.09-2021.07：中国科学院昆明植物研究所，理学博士

2015.09-2018.07：中国科学院昆明植物研究所，理学硕士

2011.09-2015.07：云南农业大学，农学学士

二、研究方向

主要从事药用植物和内生真菌的次生代谢产物及其生物活性研究，利用天然药物化学、量子化学、核磁共振、质谱等多学科技术交叉融合，研究开发免疫抑制、抗肿瘤、抗微生物等创新药物。

三、主持的科研项目

(1)国家自然科学基金青年基金项目, 82204239，2023-01至2025-12，主持

(2)湖北省自然科学基金青年基金, 2022CFB920，2022-12至2024-06，主持

(3)湖北省教育厅科学技术研究计划指导性项目,QZY25009, 2025.06-2027.06,主持

(4)中央高校基本科研业务费专项资金自科青年项目, CZQ23047, 2023-04至2026-04，主持

(5)安徽省活性天然产物重点实验室开放课题,APKLBNP202601, 2025-10-2027.10，主持

四、获奖及荣誉

2025年获评校级优秀班导师

2024年6月入选湖北省第十三批博士服务团

2024年获中南民族大学教学竞赛三等奖

2021年获第十三届“全国大学生药苑论坛”(国家级)二等奖1项

2023年获第十五届“全国大学生药苑论坛”(国家级)二等奖2项、优秀壁报奖、优秀论文奖

2024年获第十六届“全国大学生药苑论坛”(国家级)三等奖1项

多次获评中南民族大学“创新创业优秀指导教师”

五、代表性研究成果

(1) Xu Fan¹, Li Zheng‑Hui¹, Feng Meng‑Lin, Jin Jia‑Yu,Shi Bao‑Bao* and Liu Ji‑Kai* Monoterpene indole alkaloids from the aerial parts ofOphiorrhiza brevidentataand their immunological activities.Natural Products and Bioprospecting, 2026, 16, 20.

(2) Jin Jia-Yu¹, Xu Fan¹, Du Chun-Hao, Zou Li-Na, Huang Ting, Ma Qin, Zhao Ping, Li Zheng-Hui,Shi Bao-Bao^⁎and Liu Ji-Kai^⁎. Ophiogluconoid A: the first pimarane-type diterpenoid glucoside with immunosuppressive activity fromOphiorrhiza brevidentata.Tetrahedron Letters, 2026, 174, 155880.

(3) Feng MengLin,Li ZhengHui,Shi BaoBao*, Progress on 3-Nitropropionic Acid Derivatives. Biomolecules, 2025, 15(8),1066.

(4)Shi Baoao, Lu Jingsong, Wu Jing, Bao Meifen, Cai, Xianghai , Symmetric cytotoxic trimeric and dimeric indole alkaloids isolated fromBousigonia angustifolia.Organic Chemistry Frontiers, 2021, 8(11): 2601-2607.

(5)Shi Baobao, Kongkiatpaiboon Sumet, Chen Gao, Schinnerl Johann, Cai* Xianghai, Nematocidal alkaloids from the roots ofStemona mairei(H.Lév.)K.Krause and identification of their pharmacophoric moiety.Bioorganic Chemistry,2023, 130: 106239.

(6) Ai Honglian¹,Shi Baobao¹, Li Wei¹, He Juan, Li Zhenghui, Feng Tao*, Liu Jikai*, Bipolarithizole A, an antifungal phenylthiazole-Sativene merosesquiterpenoid from potato endophytic fungusBipolaris eleusines.Organic Chemistry Frontiers, 2022, 9(7): 1814-1819.

(7)Shi BaoBao¹, Tian Chun¹, Lv Xiao, Schinnerl Johann, Ye Ke, Guo Hui, Xu Fan, He Yu, Ai, HongLian* ; Liu JiKai*, Boerelasins A-D, Four Unprecedented Cytochalasins from the Endophytic Fungus Boeremia Exigua.Journal of Organic Chemistry, 2023, 88: 13926-13933

(8)Shi Baobao¹, Ai Honglian¹, Duan Kaiting, Feng Tao*, Liu Jikai*, Ophiorrhines F and G, key biogenetic intermediates of ophiorrhine Alkaloids fromOphiorrhiza japonicaand their immunosuppressant activities.Journal of Natural Products, 2022, 85(2): 453-457.

(9)Shi BaoBao¹, Xu Fan¹, Zhang GuangRu, He Yu, Liu Qing, Feng MengLin, Li ZhengHui*, Liu JiKai*. Glucoconjugated monoterpene indole alkaloids with xanthine oxidase inhibitory activity fromOphiorrhiza japonica.Phytochemistry, 2024, 224, 114169.

(10) Fan YinZhong, Tian Chun, Tong ShunYao, Liu Qing, Xu Fan,Shi BaoBao*, Ai HongLian*, Liu JiKai*,Chromones from the endophytic fungus Bipolaris eleusines.Phytochemistry, 2024, 221: 114046.

(11) Fan YinZhong,Shi BaoBao*. Endophyticfungi from thefourstaplecrops andtheirsecondarymetabolites.International Journal of Molecular Sciences,2024, 25(11):6057.

(12) Ai Honglian¹, Lv Xiao¹, Ye Ke, Wang Mengxi, Huang Rong,Shi, Baobao*, Li, Zhenghui*.Four new highly oxygenated eremophilane sesquiterpenes from an endophytic fungusBoeremia exiguaIsolated fromFritillaria hupehensis.Journal of Fungi, 2022, 8:492.

(13)Shi Baobao, Chen, Jing, Bao, Meifen, Zeng Ying*, Cai, Xianghai*.Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.Phytochemistry, 2019, 166: 112060.

(14) Zhang Xian, Fan Yinzhong, Ye Ke, Pan Xiaoyan, Ma Xujun, Ai Honglian*,Shi Baobao*, Liu Jikai*.Six unprecedented cytochalasin derivatives from the potato endophytic fungus Xylaria curta E10 and their cytotoxicity.Pharmaceuticals, 2023, 16: 193

(15)Shi Baoao¹, Zhang Guangru¹, Li Zhenghui*, Liu Jikai*.Three new oxygenated yohimbane-type alkaloids from Ophiorrhiza japonica.Fitoterapia, 2023, 166:105442.

(16)Shi Baoao, Wang Fang, Chen Gao, Schinnerl Johann*, Zeng Ying*, Cai*, Xianghai.Dimeric and monomeric dihydrostilbenes from the roots of Stemona mairei together with their hypoglycemic activities.Tetrahedron, 2021, 79: 131783.

(17)Tian Chun, Xu Fan, He Yu, Ai Hong-Lian,Shi BaoBao*, Liu JiKai,*Isolation, absolute configuration and immunosuppressant activities of pyrrole and furanone derivatives from the edible mushroom Grifolafrondose.Phytochemistry Letters, 2024, 61, 242-243.

(18) Xu Fan¹, Pan Xiaoyan¹, Cai Baixiang, Fan Yinzhong,Shi Baobao*, Liu Jikai*,Currephila A, a new chromanol derivative from the endophytic fungus Curreya pityophila.Records of Natural Products, 2024, 18,285-289.

六、近年授权专利

(1)石宝宝,刘吉开,艾洪莲,冯涛,李正辉。一种来源于日本蛇根草的新型异胡豆苷类衍生物及其制备方法和应用，ZL202210074390.1

(2)刘吉开，石宝宝，黄蓉，王献，陈乾，董智慧，沈慧慧，伍兴。一种细叶萼距花精致组分和单体化合物的制备方法及其在化妆品中的应用, ZL202310428961.1

(3)石宝宝，田淳，吕晓，艾洪莲，李正辉。一种新颖骨架类型细胞松弛素及其在制备具有抗肿瘤活性的药物中的应用，ZL202310570234.9

(4)石宝宝，何瑜，魏月萍，艾洪莲，李正辉，高丽，田喆。一种源于炭团菌发酵产物的三硝基丙酸类衍生物及其制备方法和应用，ZL 202510277008.0

(5)石宝宝，何瑜，高丽，冯梦琳，艾洪莲，李正辉。一种具有白蚁防治活性的三硝基丙酸类衍生物及其制备方法和应用。ZL 202510277098.3

(6)石宝宝，何瑜，高丽，冯梦琳，艾洪莲，李正辉。一种具有白蚁防治活性的三硝基丙酸类衍生物及其制备方法和应用。ZL 202510402492.5